Coagulation factor XIIIa cross-links amyloid β into dimers and oligomers and to blood proteins

In cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD), the amyloid β (Aβ) peptide deposits along the vascular lumen, leading to degeneration and dysfunction of surrounding tissues. Activated coagulation factor XIIIa (FXIIIa) covalently cross-links proteins in blood and vasculature,...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Hur, Woosuk S., Mazinani, Nima, Lu, X. J. David, Yefet, Leeor S., Byrnes, James R., Ho, Laura, Yeon, Ju Hun, Filipenko, Sam, Wolberg, Alisa S., Jefferies, Wilfred A., Kastrup, Christian J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2019
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333891/
https://ncbi.nlm.nih.gov/pubmed/30409906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005352
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