Coagulation factor XIIIa cross-links amyloid β into dimers and oligomers and to blood proteins

In cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD), the amyloid β (Aβ) peptide deposits along the vascular lumen, leading to degeneration and dysfunction of surrounding tissues. Activated coagulation factor XIIIa (FXIIIa) covalently cross-links proteins in blood and vasculature,...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hur, Woosuk S., Mazinani, Nima, Lu, X. J. David, Yefet, Leeor S., Byrnes, James R., Ho, Laura, Yeon, Ju Hun, Filipenko, Sam, Wolberg, Alisa S., Jefferies, Wilfred A., Kastrup, Christian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333891/
https://ncbi.nlm.nih.gov/pubmed/30409906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005352
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