Coagulation factor XIIIa cross-links amyloid β into dimers and oligomers and to blood proteins

In cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD), the amyloid β (Aβ) peptide deposits along the vascular lumen, leading to degeneration and dysfunction of surrounding tissues. Activated coagulation factor XIIIa (FXIIIa) covalently cross-links proteins in blood and vasculature,...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Hur, Woosuk S., Mazinani, Nima, Lu, X. J. David, Yefet, Leeor S., Byrnes, James R., Ho, Laura, Yeon, Ju Hun, Filipenko, Sam, Wolberg, Alisa S., Jefferies, Wilfred A., Kastrup, Christian J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333891/
https://ncbi.nlm.nih.gov/pubmed/30409906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005352
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