COAGULATION FACTOR XIIIA-INHIBITOR TRIDEGIN: ON THE ROLE OF DISULFIDE BONDS FOR FOLDING, STABILITY, AND FUNCTION

Tridegin is a potent and specific 66mer peptide inhibitor of coagulation factor XIIIa with six cysteines involved in three disulfide bonds. Three of the fifteen possible 3-disulfide-bonded isomers have been identified, which share a bridge between cysteines 19 and 25. We synthesized the three possib...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Bäuml, Charlotte A., Schmitz, Thomas, Paul George, Ajay A., Sudarsanam, Monica, Hardes, Kornelia, Steinmetzer, Torsten, Holle, Lori A., Wolberg, Alisa S., Pötzsch, Bernd, Oldenburg, Johannes, Biswas, Arijit, Imhof, Diana
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650289/
https://ncbi.nlm.nih.gov/pubmed/30852892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01982
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