Synaptic distributions of pS214-tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline

Female rhesus monkeys and women are subject to age- and menopause-related deficits in working memory, an executive function mediated by the dorsolateral prefrontal cortex (dlPFC). Long-term cyclic administration of 17β-estradiol improves working memory, and restores highly plastic axospinous synapse...

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Veröffentlicht in:J Comp Neurol
Hauptverfasser: Crimins, Johanna L., Puri, Rishi, Calakos, Katina C., Yuk, Frank, Janssen, William G. M., Hara, Yuko, Rapp, Peter R., Morrison, John H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333519/
https://ncbi.nlm.nih.gov/pubmed/30408169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.24576
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