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Diverse Synaptic Distributions of G Protein-coupled Estrogen Receptor 1 in Monkey Prefrontal Cortex with Aging and Menopause

Age- and menopause-related impairment in working memory mediated by the dorsolateral prefrontal cortex (dlPFC) occurs in humans and nonhuman primates. Long-term cyclic 17β-estradiol treatment rescues cognitive deficits in aged ovariectomized rhesus monkeys while restoring highly plastic synapses. He...

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Библиографические подробности
Опубликовано в: :Cereb Cortex
Главные авторы: Crimins, Johanna L, Wang, Athena Ching-Jung, Yuk, Frank, Puri, Rishi, Janssen, William G M, Hara, Yuko, Rapp, Peter R, Morrison, John H
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909633/
https://ncbi.nlm.nih.gov/pubmed/26941383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhw050
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