LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia

Long-term exposure to elevated levels of manganese (Mn) causes manganism, a neurodegenerative disorder with Parkinson’s disease (PD)-like symptoms. Increasing evidence suggests that leucine-rich repeat kinase 2 (LRRK2), which is highly expressed in microglia and macrophages, contributes to the infla...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Kim, Judong, Pajarillo, Edward, Rizor, Asha, Son, Deok-Soo, Lee, Jayden, Aschner, Michael, Lee, Eunsook
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333340/
https://ncbi.nlm.nih.gov/pubmed/30645642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210248
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