Exendin‐4 overcomes cytokine‐induced decreases in gap junction coupling via protein kinase A and Epac2 in mouse and human islets

KEY POINTS: The pancreatic islets of Langerhans maintain glucose homeostasis through insulin secretion, where insulin secretion dynamics are regulated by intracellular Ca(2+) signalling and electrical coupling of the insulin producing β‐cells in the islet. We have previously shown that cytokines dec...

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Bibliografische gegevens
Gepubliceerd in:J Physiol
Hoofdauteurs: Farnsworth, Nikki L., Walter, Rachelle, Piscopio, Robert A., Schleicher, Wolfgang E., Benninger, Richard K. P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
Onderwerpen:
Endocrine, Nutrition and Metabolism
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6332825/
https://ncbi.nlm.nih.gov/pubmed/30412665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP276106
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