Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ

Pro-inflammatory cytokines contribute to the decline in islet function during the development of diabetes. Cytokines can disrupt insulin secretion and calcium dynamics; however, the mechanisms underlying this are poorly understood. Connexin36 gap junctions coordinate glucose-induced calcium oscillat...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Farnsworth, Nikki L., Walter, Rachelle L., Hemmati, Alireza, Westacott, Matthew J., Benninger, Richard K. P.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751367/
https://ncbi.nlm.nih.gov/pubmed/26668311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679506
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items