Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism

Oxygen (O(2)) is required for cytochrome P450 (CYP)-dependent drug metabolism. Cytoglobin (CYGB) is a unique globin expressed exclusively in hepatic stellate cells (HSCs). However, its role in O(2)-dependent metabolism in neighboring hepatocytes remains unknown. This study provides evidence that CYG...

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Pubblicato in:Lab Invest
Autori principali: Teranishi, Yuga, Matsubara, Tsutomu, Krausz, Kristopher W, Le, Thi TT, Gonzalez, Frank J, Yoshizato, Katsutoshi, Ikeda, Kazuo, Kawada, Norifumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331008/
https://ncbi.nlm.nih.gov/pubmed/25686096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2015.29
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