GTS-21 attenuates loss of body mass, muscle mass and function in rats having systemic inflammation with and without disuse atrophy

Muscle changes of critical illness are attributed to systemic inflammatory responses and disuse atrophy. GTS-21 (3-(2,4-dimethoxy-benzylidene)anabaseine), also known as DMBX-A) is a synthetic derivative of the natural product anabaseine that acts as an agonist at α7-acetylcholine receptors (α7nAChRs...

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Detalhes bibliográficos
Publicado no:Pflugers Arch
Main Authors: Schaller, Stefan J., Nagashima, Michio, Schönfelder, Martin, Sasakawa, Tomoki, Schulz, Fabian, Khan, Mohammed A. S., Kem, William R., Schneider, Gerhard, Schlegel, Jürgen, Lewald, Heidrun, Blobner, Manfred, Jeevendra Martyn, J. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330254/
https://ncbi.nlm.nih.gov/pubmed/30006848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-018-2180-6
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