GTS-21 attenuates loss of body mass, muscle mass and function in rats having systemic inflammation with and without disuse atrophy

Muscle changes of critical illness are attributed to systemic inflammatory responses and disuse atrophy. GTS-21 (3-(2,4-dimethoxy-benzylidene)anabaseine), also known as DMBX-A) is a synthetic derivative of the natural product anabaseine that acts as an agonist at α7-acetylcholine receptors (α7nAChRs...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pflugers Arch
Prif Awduron: Schaller, Stefan J., Nagashima, Michio, Schönfelder, Martin, Sasakawa, Tomoki, Schulz, Fabian, Khan, Mohammed A. S., Kem, William R., Schneider, Gerhard, Schlegel, Jürgen, Lewald, Heidrun, Blobner, Manfred, Jeevendra Martyn, J. A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330254/
https://ncbi.nlm.nih.gov/pubmed/30006848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-018-2180-6
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