Lack of caspase-3 attenuates immobilization-induced muscle atrophy and loss of tension generation along with mitigation of apoptosis and inflammation

INTRODUCTION: Immobilization by casting induces disuse muscle atrophy (DMA). METHODS: Using wild type (WT) and caspase-3 knockout (KO) mice, we evaluated the effect of caspase-3 on muscle mass, apoptosis and inflammation during DMA. RESULTS: Caspase-3 deficiency significantly attenuated muscle mass...

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Main Authors: Zhu, Shimei, Nagashima, Michio, Khan, Mahammad A.S, Yasuhara, Shingo, Kaneki, Masao, Jeevendra Martyn, J. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634903/
https://ncbi.nlm.nih.gov/pubmed/23401051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mus.23642
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