Primary Role of Functional Ischemia, Quantitative Evidence for the Two-Hit Mechanism, and Phosphodiesterase-5 Inhibitor Therapy in Mouse Muscular Dystrophy

BACKGROUND: Duchenne Muscular Dystrophy (DMD) is characterized by increased muscle damage and an abnormal blood flow after muscle contraction: the state of functional ischemia. Until now, however, the cause-effect relationship between the pathogenesis of DMD and functional ischemia was unclear. We e...

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Detalhes bibliográficos
Main Authors: Asai, Akihiro, Sahani, Nita, Kaneki, Masao, Ouchi, Yasuyoshi, Martyn, J.A. Jeevendra, Yasuhara, Shingo Egusa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950086/
https://ncbi.nlm.nih.gov/pubmed/17726536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000806
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