Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody

Anti–CTLA-4 mAb is efficacious in enhancing tumor immunity in humans. CTLA-4 is expressed by conventional T cells upon activation and by naturally occurring FOXP3(+)CD4(+) Treg cells constitutively, raising a question of how anti–CTLA-4 mAb can differentially control these functionally opposing T ce...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Ha, Danbee, Tanaka, Atsushi, Kibayashi, Tatsuya, Tanemura, Atsushi, Sugiyama, Daisuke, Wing, James Badger, Lim, Ee Lyn, Teng, Karen Wei Weng, Adeegbe, Dennis, Newell, Evan W., Katayama, Ichiro, Nishikawa, Hiroyoshi, Sakaguchi, Shimon
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329979/
https://ncbi.nlm.nih.gov/pubmed/30587582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812186116
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