Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis

Interferons (IFNs) are critical determinants in immune-competence and autoimmunity, and are endogenously regulated by a low-level constitutive feedback loop. However, little is known about the functions and origins of constitutive IFN. Recently, lipopolysaccharide (LPS)-induced IFN was implicated as...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Sarhan, Joseph, Liu, Beiyun C., Muendlein, Hayley I., Weindel, Chi G., Smirnova, Irina, Tang, Amy Y., Ilyukha, Vladimir, Sorokin, Maxim, Buzdin, Anton, Fitzgerald, Katherine A., Poltorak, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329789/
https://ncbi.nlm.nih.gov/pubmed/29786074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0122-7
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