Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses

Legionella pneumophila elicits caspase-11-driven macrophage pyroptosis through guanylate-binding proteins (GBPs) encoded on chromosome 3. It has been proposed that microbe-driven IFN upregulates GBPs to facilitate pathogen vacuole rupture and bacteriolysis preceding caspase-11 activation. We show he...

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Publicado no:Cell Rep
Main Authors: Liu, Beiyun C., Sarhan, Joseph, Panda, Alexander, Muendlein, Hayley I., Ilyukha, Vladimir, Coers, Jörn, Yamamoto, Masahiro, Isberg, Ralph R., Poltorak, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063733/
https://ncbi.nlm.nih.gov/pubmed/29972777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.012
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