Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pathway inhibitors in BRAF-mutant melanoma

BRAF and MEK inhibitors have shown remarkable clinical efficacy in BRAF-mutant melanoma; however, most patients develop resistance, which limits the clinical benefit of these agents. In this study, we found that the human melanoma cell clones, A375-DR and A375-TR, with acquired resistance to BRAF in...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Gao, Ming-zhao, Wang, Hong-bin, Chen, Xiang-ling, Cao, Wen-ting, Fu, Li, Li, Yun, Quan, Hai-tian, Xie, Cheng-ying, Lou, Li-guang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329746/
https://ncbi.nlm.nih.gov/pubmed/29777202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0020-z
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