The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors

The response of BRAF-mutant melanoma patients to BRAF inhibitors is dramatically impaired by secondary resistances and rapid relapse. So far, the molecular mechanisms driving these resistances are not completely understood. Here, we show that, in BRAF-mutant melanoma cells, inhibition of BRAF or its...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Delmas, Audrey, Cherier, Julia, Pohorecka, Magdalena, Medale-Giamarchi, Claire, Meyer, Nicolas, Casanova, Anne, Sordet, Olivier, Lamant, Laurence, Savina, Ariel, Pradines, Anne, Favre, Gilles
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558149/
https://ncbi.nlm.nih.gov/pubmed/26098773
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