The RAS‐related GTPase RHOB confers resistance to EGFR‐tyrosine kinase inhibitors in non‐small‐cell lung cancer via an AKT‐dependent mechanism

Although lung cancer patients harboring EGFR mutations benefit from treatment with EGFR‐tyrosine kinase inhibitors (EGFR‐TKI), most of them rapidly relapse. RHOB GTPase is a critical player in both lung carcinogenesis and the EGFR signaling pathway; therefore, we hypothesized that it could play a ro...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Calvayrac, Olivier, Mazières, Julien, Figarol, Sarah, Marty‐Detraves, Claire, Raymond‐Letron, Isabelle, Bousquet, Emilie, Farella, Magali, Clermont‐Taranchon, Estelle, Milia, Julie, Rouquette, Isabelle, Guibert, Nicolas, Lusque, Amélie, Cadranel, Jacques, Mathiot, Nathalie, Savina, Ariel, Pradines, Anne, Favre, Gilles
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286377/
https://ncbi.nlm.nih.gov/pubmed/28003335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606646
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