Methotrexate chemotherapy induces persistent tri-glial dysregulation that underlies chemotherapy-related cognitive impairment

Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who r...

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Gepubliceerd in:Cell
Hoofdauteurs: Gibson, Erin M., Nagaraja, Surya, Ocampo, Alfonso, Tam, Lydia T., Wood, Lauren S., Pallegar, Praveen N., Greene, Jacob J., Geraghty, Anna C., Goldstein, Andrea K., Ni, Lijun, Woo, Pamelyn J., Barres, Ben A., Liddelow, Shane, Vogel, Hannes, Monje, Michelle
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329664/
https://ncbi.nlm.nih.gov/pubmed/30528430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.049
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