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Methotrexate chemotherapy induces persistent tri-glial dysregulation that underlies chemotherapy-related cognitive impairment

Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who r...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Gibson, Erin M., Nagaraja, Surya, Ocampo, Alfonso, Tam, Lydia T., Wood, Lauren S., Pallegar, Praveen N., Greene, Jacob J., Geraghty, Anna C., Goldstein, Andrea K., Ni, Lijun, Woo, Pamelyn J., Barres, Ben A., Liddelow, Shane, Vogel, Hannes, Monje, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329664/
https://ncbi.nlm.nih.gov/pubmed/30528430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.049
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