Microbubble-mediated delivery of human adenoviruses does not elicit innate and adaptive immunity response in an immunocompetent mouse model of prostate cancer

BACKGROUND: Gene transfer to malignant sites using human adenoviruses (hAds) has been limited because of their immunogenic nature and host specificity. Murine cells often lack some of the receptors needed for hAds attachment, thus murine cells are generally non-permissive for human adenoviral infect...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: De Carlo, Flavia, Thomas, Litty, Brooke, Bell, Varney, Elliot T., Nande, Rounak, Boskovic, Olivia, Marshall, Gailen D., Claudio, Pier Paolo, Howard, Candace M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329087/
https://ncbi.nlm.nih.gov/pubmed/30635014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1771-0
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