Loss of the mitochondrial i‐AAA protease YME1L leads to ocular dysfunction and spinal axonopathy

Disturbances in the morphology and function of mitochondria cause neurological diseases, which can affect the central and peripheral nervous system. The i‐AAA protease YME1L ensures mitochondrial proteostasis and regulates mitochondrial dynamics by processing of the dynamin‐like GTPase OPA1. Mutatio...

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Foilsithe in:EMBO Mol Med
Main Authors: Sprenger, Hans‐Georg, Wani, Gulzar, Hesseling, Annika, König, Tim, Patron, Maria, MacVicar, Thomas, Ahola, Sofia, Wai, Timothy, Barth, Esther, Rugarli, Elena I, Bergami, Matteo, Langer, Thomas
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2018
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328943/
https://ncbi.nlm.nih.gov/pubmed/30389680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809288
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