A dual‐AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice

Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses require otoferlin. Deafness DFNB9, caused by mutations in the OTOF gene encoding otoferlin, might be treated by transferring wild‐type otoferlin cDNA into IHCs, which is difficult due to the large size of th...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Al‐Moyed, Hanan, Cepeda, Andreia P, Jung, SangYong, Moser, Tobias, Kügler, Sebastian, Reisinger, Ellen
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328916/
https://ncbi.nlm.nih.gov/pubmed/30509897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809396
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