Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation

With the aim of discovering novel IDO1 inhibitors, a combined similarity search and molecular docking approach was employed to the discovery of 32 hit compounds. Testing the screened hit compounds has led to several novel submicromolar inhibitors. Especially for compounds LVS-019 with cyanopyridine...

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Dettagli Bibliografici
Pubblicato in:J Enzyme Inhib Med Chem
Autori principali: Xu, Xi, Ren, Jie, Ma, Yinghe, Liu, Hongting, Rong, Quanjin, Feng, Yifan, Wang, Yameng, Cheng, Yu, Ge, Ruijia, Li, Zhiyu, Bian, Jinlei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327983/
https://ncbi.nlm.nih.gov/pubmed/30734612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1480614
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