Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation

With the aim of discovering novel IDO1 inhibitors, a combined similarity search and molecular docking approach was employed to the discovery of 32 hit compounds. Testing the screened hit compounds has led to several novel submicromolar inhibitors. Especially for compounds LVS-019 with cyanopyridine...

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Библиографические подробности
Опубликовано в: :J Enzyme Inhib Med Chem
Главные авторы: Xu, Xi, Ren, Jie, Ma, Yinghe, Liu, Hongting, Rong, Quanjin, Feng, Yifan, Wang, Yameng, Cheng, Yu, Ge, Ruijia, Li, Zhiyu, Bian, Jinlei
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2019
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327983/
https://ncbi.nlm.nih.gov/pubmed/30734612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1480614
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