Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation

With the aim of discovering novel IDO1 inhibitors, a combined similarity search and molecular docking approach was employed to the discovery of 32 hit compounds. Testing the screened hit compounds has led to several novel submicromolar inhibitors. Especially for compounds LVS-019 with cyanopyridine...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Enzyme Inhib Med Chem
Egile Nagusiak: Xu, Xi, Ren, Jie, Ma, Yinghe, Liu, Hongting, Rong, Quanjin, Feng, Yifan, Wang, Yameng, Cheng, Yu, Ge, Ruijia, Li, Zhiyu, Bian, Jinlei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2019
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327983/
https://ncbi.nlm.nih.gov/pubmed/30734612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1480614
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