Neurog3-independent methylation is the earliest detectable mark distinguishing pancreatic progenitor identity

In the developing pancreas, transient Neurog3-expressing progenitors give rise to four major islet-cell types, α, β, δ, and γ; when and how the Neurog3(+) cells choose cell-fate is unknown. Using single-cell RNAseq, trajectory analysis, and combinatorial lineage tracing, we showed here that the Neur...

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Pubblicato in:Dev Cell
Autori principali: Liu, Jing, Banerjee, Amrita, Herring, Charles A., Attalla, Jonathan, Hu, Ruiying, Xu, Yanwen, Shao, Qiujia, Simmons, Alan J., Dadi, Prasanna K., Wang, Sui, Jacobson, David A., Liu, Bindong, Hodges, Emily, Lau, Ken S., Gu, Guoqiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327977/
https://ncbi.nlm.nih.gov/pubmed/30620902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.11.048
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