Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism

Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Genome-wide association studies have shown variation at 14q11.2 influences ALL risk. We sought to decipher causal variant(s) at 14q11.2 and the mechanism of tumorigenesis. We show rs2239630 G>A resides in the promoter o...

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Udgivet i:Leukemia
Main Authors: Studd, James B., Yang, Minjun, Li, Zhenhua, Vijayakrishnan, Jayaram, Lu, Yi, Yeoh, Allen Eng-Juh, Paulsson, Kajsa, Houlston, Richard S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327050/
https://ncbi.nlm.nih.gov/pubmed/29977016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0184-z
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