The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene

We have cloned the genomic breakpoints for a balanced t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia. Sequence analysis of the genomic breakpoints indicated that the translocation had been mediated by an illegitimate V(D)J recombination event that d...

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Detalhes bibliográficos
Main Authors: Wang, Junjie, Jani-Sait, Sheila N., Escalon, Enrique A., Carroll, Andrew J., de Jong, Pieter J., Kirsch, Ilan R., Aplan, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16268/
https://ncbi.nlm.nih.gov/pubmed/10737801
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