β-Adrenergic signaling blocks murine CD8(+) T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress

Primary and secondary lymphoid organs are heavily innervated by the autonomic nervous system. Norepinephrine, the primary neurotransmitter secreted by post-ganglionic sympathetic neurons, binds to and activates β-adrenergic receptors expressed on the surface of immune cells and regulates the functio...

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Bibliografische gegevens
Gepubliceerd in:Cancer Immunol Immunother
Hoofdauteurs: Qiao, Guanxi, Bucsek, Mark J., Winder, Nicolette M., Chen, Minhui, Giridharan, Thejaswini, Olejniczak, Scott H., Hylander, Bonnie L., Repasky, Elizabeth A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Berlin Heidelberg 2018
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326964/
https://ncbi.nlm.nih.gov/pubmed/30229289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-018-2243-8
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