β-adrenergic signaling in mice housed at standard temperatures suppresses an effector phenotype in CD8(+) T cells and undermines checkpoint inhibitor therapy

The immune context of tumors has significant prognostic value and is predictive of responsiveness to several forms of therapy, including immunotherapy. We report here that CD8(+) T cell frequency and functional orientation within the tumor microenvironment is regulated by β(2)-adrenergic receptor (β...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Bucsek, Mark J., Qiao, Guanxi, MacDonald, Cameron R., Giridharan, Thejaswini, Evans, Lauren, Niedzwecki, Brian, Liu, Haichao, Kokolus, Kathleen M., Eng, Jason W-L, Messmer, Michelle N., Attwood, Kristopher, Abrams, Scott I., Hylander, Bonnie L., Repasky, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645237/
https://ncbi.nlm.nih.gov/pubmed/28819022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0546
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