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Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β(2)-adrenergic receptor activation
Cancer research relies heavily on murine models for evaluating the anti-tumour efficacy of therapies. Here we show that the sensitivity of several pancreatic tumour models to cytotoxic therapies is significantly increased when mice are housed at a thermoneutral ambient temperature of 30 °C compared...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4471870/ https://ncbi.nlm.nih.gov/pubmed/25756236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7426 |
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