Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β(2)-adrenergic receptor activation

Cancer research relies heavily on murine models for evaluating the anti-tumour efficacy of therapies. Here we show that the sensitivity of several pancreatic tumour models to cytotoxic therapies is significantly increased when mice are housed at a thermoneutral ambient temperature of 30 °C compared...

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Udgivet i:Nat Commun
Main Authors: Eng, Jason W.-L., Reed, Chelsey B., Kokolus, Kathleen M., Pitoniak, Rosemarie, Utley, Adam, Bucsek, Mark J., Ma, Wen Wee, Repasky, Elizabeth A., Hylander, Bonnie L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471870/
https://ncbi.nlm.nih.gov/pubmed/25756236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7426
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