β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

Catecholamines released by sympathetic nerves can activate adrenergic receptors present on nearly every cell type, including myeloid-derived suppressor cells (MDSCs). Using in vitro systems, murine tumor models in wild-type and genetically modified (β2-AR(–/–)) mice, and adoptive transfer approaches...

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Pubblicato in:J Clin Invest
Autori principali: Mohammadpour, Hemn, MacDonald, Cameron R., Qiao, Guanxi, Chen, Minhui, Dong, Bowen, Hylander, Bonnie L., McCarthy, Philip L., Abrams, Scott I., Repasky, Elizabeth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877316/
https://ncbi.nlm.nih.gov/pubmed/31566578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129502
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