Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development

Animal cloning can be achieved through somatic cell nuclear transfer (SCNT), although the live birth rate is relatively low. Recent studies have identified H3K9me3 in donor cells and abnormal Xist activation as epigenetic barriers that impede SCNT. Here we overcome these barriers using a combination...

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Pubblicato in:Cell Stem Cell
Autori principali: Matoba, Shogo, Wang, Huihan, Jiang, Lan, Lu, Falong, Iwabuchi, Kumiko A., Wu, Xiaoji, Inoue, Kimiko, Yang, Lin, Press, William, Lee, Jeannie T., Ogura, Atsuo, Shen, Li, Zhang, Yi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326833/
https://ncbi.nlm.nih.gov/pubmed/30033120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.06.008
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