TOE1 acts as a 3′ exonuclease for telomerase RNA and regulates telomere maintenance

In human cells, telomeres are elongated by the telomerase complex that contains the reverse transcriptase hTERT and RNA template TERC/hTR. Poly(A)-specific ribonuclease (PARN) is known to trim hTR precursors by removing poly(A) tails. However, the precise mechanism of hTR 3′ maturation remains large...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Deng, Tingting, Huang, Yan, Weng, Kai, Lin, Song, Li, Yujing, Shi, Guang, Chen, Yali, Huang, Junjiu, Liu, Dan, Ma, Wenbin, Songyang, Zhou
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
Ämnen:
RNA Prot Comp
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326811/
https://ncbi.nlm.nih.gov/pubmed/30371886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1019
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