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A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension

[Image: see text] Because of its importance for the origin of life, the nonenzymatic copying of RNA templates has been the subject of intense study for several decades. Previous characterizations of template-directed primer extension using 5′-phosphoryl-2-methylimidazole-activated nucleotides (2-MeI...

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Pubblicato in:J Am Chem Soc
Autori principali: Walton, Travis, Szostak, Jack W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2016
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326528/
https://ncbi.nlm.nih.gov/pubmed/27552367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b07977
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