The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models

In covariate (sub)models of population pharmacokinetic models, most covariates are normalized to the median value; however, for body weight, normalization to 70 kg or 1 kg is often applied. In this article, we illustrate the impact of normalization weight on the precision of population clearance (CL...

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Bibliographic Details
Published in:Clin Pharmacokinet
Main Authors: Goulooze, Sebastiaan C., Völler, Swantje, Välitalo, Pyry A. J., Calvier, Elisa A. M., Aarons, Leon, Krekels, Elke H. J., Knibbe, Catherijne A. J.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2018
Subjects:
Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325985/
https://ncbi.nlm.nih.gov/pubmed/29572663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-018-0652-7
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