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A combination of the PI3K pathway inhibitor plus cell cycle pathway inhibitor to combat endocrine resistance in hormone receptor-positive breast cancer: a genomic algorithm-based treatment approach

Cyclin-dependent kinase 4 (CDK4) and CDK6 together with D-type cyclins (D1, D2 and D3) to promote cell cycle entry and progression through G1 by inactivating retinoblastoma protein (RB) by inhibiting an INK4 family of CDK inhibitors (CDKN2A/B). Selective cyclin-dependent kinase inhibitors are game c...

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Bibliografiske detaljer
Udgivet i:Am J Cancer Res
Main Authors: Gul, Anita, Leyland-Jones, Brain, Dey, Nandini, De, Pradip
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325472/
https://ncbi.nlm.nih.gov/pubmed/30662797
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