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Doubling Down on the PI3K-AKT-mTOR Pathway Enhances the Antitumor Efficacy of PARP Inhibitor in Triple Negative Breast Cancer Model beyond BRCA-ness

Phosphoinositide 3-kinase (PI3K) pathway, in addition to its pro-proliferative and antiapoptotic effects on tumor cells, contributes to DNA damage repair (DDR). We hypothesized that GDC-0980, a dual PI3K-mammalian target of rapamycin (mTOR) inhibitor, would induce an efficient antitumor effect in BR...

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Главные авторы: De, Pradip, Sun, Yuling, Carlson, Jennifer H, Friedman, Lori S, Leyland-Jones, Brian R, Dey, Nandini
Формат: Artigo
Язык:Inglês
Опубликовано: Neoplasia Press Inc. 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924548/
https://ncbi.nlm.nih.gov/pubmed/24563619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1593/neo.131694
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