Targeting ubiquitin-activating enzyme induces ER stress–mediated apoptosis in B-cell lymphoma cells

Alterations in the ubiquitin proteasome system (UPS) leave malignant cells in heightened cellular stress, making them susceptible to proteasome inhibition. However, given the limited efficacy of proteasome inhibitors in non-Hodgkin lymphoma (NHL), novel approaches to target the UPS are needed. Here,...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Best, Scott, Hashiguchi, Taylor, Kittai, Adam, Bruss, Nur, Paiva, Cody, Okada, Craig, Liu, Tingting, Berger, Allison, Danilov, Alexey V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325297/
https://ncbi.nlm.nih.gov/pubmed/30617217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018026880
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