Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma

The antiapoptotic Bcl-2 family member Bfl-1 is up-regulated in many human tumors in which nuclear factor-κB (NF-κB) is implicated and contributes significantly to tumor cell survival and chemoresistance. We previously found that NF-κB induces transcription of bfl-1 and that the Bfl-1 protein is also...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Fan, Gaofeng, Simmons, Matthew J., Ge, Sheng, Dutta-Simmons, Jui, Kucharczak, Jérôme, Ron, Yacov, Weissmann, David, Chen, Chiann-Chyi, Mukherjee, Chandreyee, White, Eileen, Gélinas, Céline
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Hematology 2010
נושאים:
Lymphoid Neoplasia
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867266/
https://ncbi.nlm.nih.gov/pubmed/20185581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-236760
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