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Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma
The antiapoptotic Bcl-2 family member Bfl-1 is up-regulated in many human tumors in which nuclear factor-κB (NF-κB) is implicated and contributes significantly to tumor cell survival and chemoresistance. We previously found that NF-κB induces transcription of bfl-1 and that the Bfl-1 protein is also...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867266/ https://ncbi.nlm.nih.gov/pubmed/20185581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-236760 |
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