Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis

Upon invasion of Lewis rat macrophages, Toxoplasma rapidly induces programmed cell death (pyroptosis), which prevents Toxoplasma replication, possibly explaining the resistance of the Lewis rat to Toxoplasma. Using a chemical mutagenesis screen, we identified Toxoplasma mutants that no longer induce...

Full description

Saved in:
Bibliographic Details
Published in:mBio
Main Authors: Wang, Yifan, Cirelli, Kimberly M., Barros, Patricio D. C., Sangaré, Lamba Omar, Butty, Vincent, Hassan, Musa A., Pesavento, Patricia, Mete, Asli, Saeij, Jeroen P. J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325250/
https://ncbi.nlm.nih.gov/pubmed/30622189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02388-18
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items