Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis

Upon invasion of Lewis rat macrophages, Toxoplasma rapidly induces programmed cell death (pyroptosis), which prevents Toxoplasma replication, possibly explaining the resistance of the Lewis rat to Toxoplasma. Using a chemical mutagenesis screen, we identified Toxoplasma mutants that no longer induce...

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Vydáno v:mBio
Hlavní autoři: Wang, Yifan, Cirelli, Kimberly M., Barros, Patricio D. C., Sangaré, Lamba Omar, Butty, Vincent, Hassan, Musa A., Pesavento, Patricia, Mete, Asli, Saeij, Jeroen P. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325250/
https://ncbi.nlm.nih.gov/pubmed/30622189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02388-18
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