Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages

Macrophages play an essential role in the early immune response against Toxoplasma and are the cell type preferentially infected by the parasite in vivo. Interferon gamma (IFNγ) elicits a variety of anti-Toxoplasma activities in macrophages. Using a genome-wide CRISPR screen we identify 353 Toxoplas...

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Udgivet i:Nat Commun
Main Authors: Wang, Yifan, Sangaré, Lamba Omar, Paredes-Santos, Tatiana C., Hassan, Musa A., Krishnamurthy, Shruthi, Furuta, Anna M., Markus, Benedikt M., Lourido, Sebastian, Saeij, Jeroen P. J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567896/
https://ncbi.nlm.nih.gov/pubmed/33067458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18991-8
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