Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus

Human adenovirus (AdV) can cause fatal disease in immune-suppressed individuals, but treatment options are limited, in part because the antiviral cytidine analog cidofovir (CDV) is nephrotoxic. The investigational agent brincidofovir (BCV) is orally bioavailable, nonnephrotoxic, and generates the sa...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Chamberlain, Jeffrey M., Sortino, Katherine, Sethna, Phiroze, Bae, Andrew, Lanier, Randall, Bambara, Robert A., Dewhurst, Stephen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325223/
https://ncbi.nlm.nih.gov/pubmed/30397065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01925-18
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