Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus

Human adenovirus (AdV) can cause fatal disease in immune-suppressed individuals, but treatment options are limited, in part because the antiviral cytidine analog cidofovir (CDV) is nephrotoxic. The investigational agent brincidofovir (BCV) is orally bioavailable, nonnephrotoxic, and generates the sa...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Chamberlain, Jeffrey M., Sortino, Katherine, Sethna, Phiroze, Bae, Andrew, Lanier, Randall, Bambara, Robert A., Dewhurst, Stephen
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2018
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325223/
https://ncbi.nlm.nih.gov/pubmed/30397065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01925-18
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