Argonaute 2 drives miR-145-5p-dependent gene expression program in breast cancer cells

To perform their regulatory functions, microRNAs (miRNAs) must assemble with any of the four mammalian Argonaute (Ago) family of proteins, Ago1–4, into an effector complex known as the RNA-induced silencing complex (RISC). While the mature miRNA guides the RISC complex to its target mRNA, the Ago pr...

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Vydáno v:Cell Death Dis
Hlavní autoři: Bellissimo, Teresa, Tito, Claudia, Ganci, Federica, Sacconi, Andrea, Masciarelli, Silvia, Di Martino, Giuseppe, Porta, Natale, Cirenza, Mirko, Sorci, Melissa, De Angelis, Luciana, Rosa, Paolo, Calogero, Antonella, Fatica, Alessandro, Petrozza, Vincenzo, Fontemaggi, Giulia, Blandino, Giovanni, Fazi, Francesco
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325137/
https://ncbi.nlm.nih.gov/pubmed/30622242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1267-5
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