Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

Genomic instability (IN) is a common feature of many human cancers. The TP53 tumour suppressor gene is mutated in approximately half of human cancers. Here, we show that BRCA1 and RAD17 genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-fun...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Valenti, Fabio, Ganci, Federica, Fontemaggi, Giulia, Sacconi, Andrea, Strano, Sabrina, Blandino, Giovanni, Di Agostino, Silvia
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467386/
https://ncbi.nlm.nih.gov/pubmed/25650659
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker