The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis

Mitochondrial topoisomerase IB (TOP1MT) is a nuclear-encoded topoisomerase, exclusively localized to mitochondria, which resolves topological stress generated during mtDNA replication and transcription. Here, we report that TOP1MT is overexpressed in cancer tissues and demonstrate that TOP1MT defici...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Baechler, S. A., Factor, V. M., Dalla Rosa, I., Ravji, A., Becker, D., Khiati, S., Miller Jenkins, L. M., Lang, M., Sourbier, C., Michaels, S. A., Neckers, L. M., Zhang, H. L., Spinazzola, A., Huang, S. N., Marquardt, J. U., Pommier, Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325124/
https://ncbi.nlm.nih.gov/pubmed/30622257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07922-3
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