Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1

Muscle dysfunction is common in patients with ARDS and is associated with morbidity that can persist for years after discharge. In a mouse model of severe influenza A pneumonia, we found the pro-inflammatory cytokine IL-6 was necessary for the development of muscle dysfunction. Treatment with an FDA...

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Publicado no:J Immunol
Main Authors: Radigan, Kathryn A., Nicholson, Trevor T., Welch, Lynn C., Chi, Monica, Amarelle, Luciano, Angulo, Martín, Shigemura, Masahiko, Shigemura, Atsuko, Runyan, Constance E., Morales-Nebreda, Luisa, Perlman, Harris, Ceco, Ermelinda, Lecuona, Emilia, Dada, Laura A., Misharin, Alexander V., Mutlu, Gokhan M., Sznajder, Jacob I., Budinger, G.R. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324970/
https://ncbi.nlm.nih.gov/pubmed/30530483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701433
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